Targeted Chemotherapy at Tubulin: A Tale of Nature’s Power

Targeted chemotherapy at tubulin has been the first “magic bullet” for cancer treatment. Tubulin, an essential component of cellular microtubules, plays a vital role in cell division, offering a strategic therapeutic target to interfere with the uncontrolled growth of cancer cells and thus allowing the development of broad-spectrum oncological therapies.

This presentation will explore how antimicrotubule agents, derived from natural and synthetic sources, have been developed to stabilize or destabilize microtubules, effectively halting the proliferation of cancer cells. Taxanes and vinca alkaloids, among others, will be presented as key examples of how nature has inspired potent cancer treatments.

The challenges associated with tubulin-targeted chemotherapy, including drug resistance and side effects, will be discussed, along with current research strategies aimed at overcoming these obstacles. The presentation will also address the future of tubulin-targeted chemotherapy, highlighting the development of new agents with greater specificity and reduced toxicity, as well as the integration of these treatments into combination therapies.

Through this presentation, a comprehensive overview will be provided on how the study of tubulin and its interaction with various chemotherapeutic agents has led to significant advances in cancer treatment. The crucial role of ongoing research in discovering innovative solutions to combat this disease will be emphasized, demonstrating the combined power of nature and science in the quest for a cure.

Ponente:

Dr. Fernándo Díaz Pereira

Head of the Unit for the Development of Biological, Immunological, and Chemical Drugs
Spanish National Research Council (CSIC)